Why are some people not affected by edibles?

Sunday, May 23, 2021

As researchers are continuing to learn more about the human body’s endocannabinoid system, they’re discovering that some cannabis consumers are incapable of feeling the psychoactive effects that are typically produced by edibles. For a long time there have been very few theories to explain this trend, but a recent hypothesis that’s been gaining traction in the scientific community is a promising start to finding real answers!

This ground-breaking hypothesis is that people who have an abnormal variation of a key liver enzyme are too efficient at processing THC they’ve ingested. As we’ve previously covered, when THC is digested it’s processed by the liver and broken down to become more bioavailable; anyone who doesn’t feel the effects of ingested THC are likely having it broken down and processed so quickly that it doesn’t have the time it needs to produce psychoactive effects.

Other variables are also believed to play a role in peoples’ inability to feel psychoactive effects from cannabis edibles, such as how easily their bodies are able to absorb and metabolize fats. Researchers have even come to believe that this trend stems from a genetic source! They’ve found that a strong majority of subjects who are unable to get high from edibles have at least one family member with the same issue. These fascinating realizations are just the beginning of many discoveries that will shape what we all know about cannabis and the human endocannabinoid system!

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